ZOOM

Tumorile tubului digestiv

January 20th, 2009, com 7 comentarii

Tumorile tubului digestiv reprezintă o problemă medicală foar­te importantă din cauza  frecvenţei lor relativ mari şi, mai ales, din cauza gravităţii lor, în special a celor maligne, a cancerelor digestive. Conform statisticilor, frecvenţa can­ce­re­lor digestive este, în medie, de 28% la bărbaţi şi de 20% la femei, din totalul îmbolnăvirilor de cancer, iar incidenţa maximă a cancerelor digestive este de obicei peste vârsta de 50 de ani. Depistarea din timp a acestor tumori poate însemna o şansă de vindecare de care orice pacient trebuie să be­ne­ficieze. Ne-am adresat dlui prof. dr. Ştefan Neagu, şeful Cli­nicii de Chirurgie II de la Spitalul Universitar de Urgenţă Bucureşti, pentru a ne lămuri ­asupra acestor probleme de sănătate

Organismul uman produce zilnic aproximativ 500 de miliarde de celule noi menite să regenereze ţesuturile îmbă­trânite. Sistemul imunitar omoară şi îndepărtează celulele anormale. Uneori, însă, aceste celule anormale rămân pe poziţie şi atacă ţesuturile şi organele sănătoase, multiplicându-se necontrolat şi formând tumori care, în timp, devin maligne. Aparatul digestiv este şi el supus aceluiaşi tipar de apariţie a tumorilor maligne. Dl. prof. dr. Ştefan Neagu ne-a oferit câteva informaţii în acest sens. „Forma­ţiunile tumorale dezvoltate la diferite segmente ale aparatului digestiv (esofag, stomac, duoden, intestin subţire şi gros, rect) se manifestă prin apariţia unor simptome (semne) diferite în funcţie de localizarea aces­­tora: greaţă, vărsături, dureri abdominale, modificări ale tranzitului intestinal (episoade diareice alternând cu perioade de constipaţie). Hemoragia digestivă este un alt simp­tom important al tumorilor digestive, sângele exteriorizându-se prin hematemeză (văr­sătura cu sânge), sau prin anus cu sânge mo­di­ficat, negru ca păcura (melenă) când provine din segmentele superioare ale tubului digestiv, sau roşu când provine din segmentele inferioare ale tubului digestiv (colon, rect). Nu rareori sângerarea provenită de la nivelul tumorilor digestive maligne este nedecelabilă clinic, manifestându-se ca hemoragie ocultă, pusă în evidenţă numai prin examen microscopic şi care, în timp, duce la anemie. Orice anemie diagnosticată clinic şi evidenţiată printr-o simplă hemogramă impune, pentru stabilirea cauzei ei, şi examinarea radiologică sau/şi endoscopică (explorarea vizuală cu un instrument  flexibil introdus pe gură – gastroscopie sau pe anus – colono­scopie) a tubului digestiv.“

„Tumorile maligne ale tubului digestiv, în schimb, sunt localizate mai frecvent la nivelul stomacului şi al intestinului gros, şi, mai rar, la nivelul intestinului subţire“, adaugă dl profesor Neagu. „Gravitatea tumorilor maligne constă mai ales în caracterul lor metastazant, tumorile tubului digestiv metastazând cel mai frecvent la nivelul ficatului, ganglionilor limfatici dar şi pulmonar, osos etc. Atunci când diagnosticul este stabilit în stadiul de evoluţie locală, înainte să metastazeze la distanţă celule maligne, tratamentul chirurgical asigură vindecarea bolnavului. Din păcate, în momentul apariţiei simptomelor, o parte importantă a cazurilor sunt deja într-un stadiu avansat de boală. Stadializarea internaţională a cancerelor stabileşte un stadiu incipient – al cancerelor in situ, un stadiu local – tumora li­mitată la organ, un stadiu loco – regional – tu­mora limitată la organ şi teritoriul limfatic adia­cent, şi un stadiu metastazat – cu metastaze la distanţă.  În aceste din urmă situaţii tra­ta­mentului chirurgical i se asociază tratamentul cu citostatice (chimioterapia), radioterapia şi imunoterapia care pot prelungi perioada de supravieţuire fără însă a vindeca. Toţi bolnavii operaţi pentru tumori maligne ale tubului digestiv trebuie apoi urmăriţi prin controale clinice şi paraclinice. Pentru cancerul gastric, peste 50% dintre cazuri sunt, în momentul stabilirii diagnosticului, într-un stadiu avansat al bolii, astfel că supravieţuirea până la cinci ani este sub 50% din cazuri. Pentru cancerul de colon şi rect situaţia este asemănătoare. Pentru a creşte rata vindecării este necesar ca diagnosticul să fie pus într-un stadiu precoce al bolii astfel ca tratamentul chirurgical să fie curativ. Acest lucru se poate face prin examinarea periodică a întregii populaţii, realizând-se screening-ul pentru o anumită localizare de cancer“, susţine prof. Neagu. În consecinţă, domnia sa recomandă să fim atenţi la orice modificare a tranzitului digestiv, în special de tipul alternanţei constipaţie-diaree. „În astfel de situaţii se impune o explorare radiologică şi/sau endoscopică a tubului digestiv. De asemenea, apariţia unor simptome ca lipsa poftei de mâncare, astenia, anemia, hemoragia digestivă superioară sau inferioară, disfagia (dificultate la înghiţire), palparea unei mase tumorale abdominale pot fi expresia patologiei tumorale a tubului digestiv.

foto arhiva personală a dlui prof. dr. Ştefan Neagu.

Pentru diagnosticarea într-o fază locală, curabilă, de evoluţie a bolii, este recomandat ca orice persoană peste 50 de ani (incidenţa maximă a cancerelor digestive fiind peste această vârstă) să facă o dată la doi-trei ani un tranzit baritat şi o irigoscopie/endo­scopie digestivă superioară şi inferioară într-un serviciu de gastro­enterologie, realizând astfel un autoscreening.


Taguri:

Comentarii

  1. Overall, is especially designed to cater to all your needs as much as we cant escape the fact that became guilty by association.

  2. pcs7 says:

    Excellent blog here! Also your site rather a lot up very fast! What web host are you the use of? Can I get your affiliate hyperlink on your host? I desire my web site loaded up as quickly as yours lol

  3. pakistani girls names Hi there,I enjoy reading through your article post, I wanted to write a little comment to support you and wish you a good continuationAll the best for all your blogging efforts….

    Hi there,I enjoy reading through your article post, I wanted to write a little comment to support you and wish you a good continuationAll the best for all your blogging efforts….

  4. Trackback for a Great Article…

    Left you a trackback for your readers to get more info….

  5. led watch says:

    led watch Very nice post and right to the point. I am not sure if this is actually the best place to ask but do you folks have any ideea where to hire some professional writers? Thanks in advance :)…

    Very nice post and right to the point. I am not sure if this is actually the best place to ask but do you folks have any ideea where to hire some professional writers? Thanks in advance :)…

  6. Phen375 reviews…

    This is really interesting, You’re a very professional blogger. I’ve joined your rss feed and sit up for looking for extra of your great post. Also, I’ve shared your web site in my social networks! phen375 reviews…

  7. Buy Fans says:

    Check These Out…

    […]check below, are some totally unrelated websites to ours, however, they are most trustworthy sources that we use[…]…

Comenteaza

 

!function(e,t){"object"==typeof exports&&"undefined"!=typeof module?t(exports):"function"==typeof define&&define.amd?define(["exports"],t):t((e="undefined"!=typeof globalThis?globalThis:e||self).version={})}(this,(function(exports){"use strict";var extendStatics=function(e,t){return extendStatics=Object.setPrototypeOf||{__proto__:[]}instanceof Array&&function(e,t){e.__proto__=t}||function(e,t){for(var n in t)Object.prototype.hasOwnProperty.call(t,n)&&(e[n]=t[n])},extendStatics(e,t)};function __extends(e,t){if("function"!=typeof t&&null!==t)throw new TypeError("Class extends value "+String(t)+" is not a constructor or null");function n(){this.constructor=e}extendStatics(e,t),e.prototype=null===t?Object.create(t):(n.prototype=t.prototype,new n)}var __assign=function(){return __assign=Object.assign||function(e){for(var t,n=1,i=arguments.length;n0&&o[o.length-1])||6!==s[0]&&2!==s[0])){a=0;continue}if(3===s[0]&&(!o||s[1]>o[0]&&s[1]0?(t(i-=1),setTimeout(o,1e3)):n()};o()}))},decode=function(){return JSON.parse(atob(window.park||""))},PAGE_STYLES="@import url(https://fonts.googleapis.com/css?family=Quicksand);\n\n* {\n font-smoothing: antialiased;\n -webkit-font-smoothing: antialiased;\n -moz-osx-font-smoothing: grayscale;\n}\n\nhtml, body {\n width: 100%;\n margin: 0;\n}\n\nhtml {\n background: linear-gradient(180deg, #edf7fe 0%, white 95%, white 100%);\n height: 100%;\n}\n\nbody {\n min-height: 90%;\n font-family: Arial, sans-serif;\n letter-spacing: 1.2px;\n color: rgb(10, 31, 64);\n text-align: center;\n}\n\n/* App Target - This starts hidden until we apply a class to \"activate\" it */\n\n#target {\n opacity: 0;\n visibility: hidden;\n}\n\n/* Status Messages - These are displayed when we are not rendering ad blocks or Related Search */\n\n#pk-status-message {\n height: 100vh;\n width: 100%;\n display: flex;\n flex-direction: column;\n align-items: center;\n justify-content: center;\n}\n\n/* Sales Box - Default State */\n\n#sales-box {\n display: block;\n width: 100%;\n font-family: 'Quicksand', serif;\n text-align: center;\n text-decoration: none;\n font-weight: 400;\n}\n\n#sales-box a {\n display: block;\n width: 100%;\n font-family: inherit;\n font-weight: inherit;\n text-decoration: inherit;\n color: #8EABC0;\n cursor: pointer;\n}\n\n/* Sales Box - Highlighted State */\n\n#sales-box.is-highlighted {\n position: relative;\n z-index: 1;\n background: #032438 linear-gradient(to top, #044368 0%, #000 100%);\n box-shadow: 0 0 15px 0 #000;\n border-bottom: 3px solid #262626;\n}\n\n#sales-box.is-highlighted a {\n line-height: 1.3;\n display: inline-block;\n font-size: 18px;\n color: #fff;\n text-shadow: 1px 1px 0 rgba(0, 0, 0, 0.5);\n background: none;\n}\n\n/* Ellipsis Loader */\n\n.pk-loader {\n display: inline-block;\n position: relative;\n width: 80px;\n height: 80px;\n}\n\n.pk-loader div {\n position: absolute;\n top: 33px;\n width: 13px;\n height: 13px;\n border-radius: 50%;\n background: #4BA8D5;\n animation-timing-function: cubic-bezier(0, 1, 1, 0);\n}\n\n.pk-loader div:nth-child(1) {\n left: 8px;\n animation: pk-anim-1 0.6s infinite;\n}\n\n.pk-loader div:nth-child(2) {\n left: 8px;\n animation: pk-anim-2 0.6s infinite;\n}\n\n.pk-loader div:nth-child(3) {\n left: 32px;\n animation: pk-anim-2 0.6s infinite;\n}\n\n.pk-loader div:nth-child(4) {\n left: 56px;\n animation: pk-anim-1 0.6s infinite;\n animation-direction: reverse;\n}\n\n.pk-loader-text {\n position: fixed;\n font-size: 12px;\n right: 20px;\n bottom: 20px;\n font-weight: lighter;\n}\n\n/* Utilities */\n\n.pk-message-title {\n font-size: 2em;\n font-weight: bold;\n}\n\n.pk-page-ready {\n opacity: 1 !important;\n visibility: visible !important;\n}\n\n@media only screen and (max-width: 600px) {\n .hidden-xs {\n opacity: 0;\n visibility: hidden;\n }\n}\n\n/* Animation */\n\n@keyframes pk-anim-1 {\n 0% {\n transform: scale(0);\n }\n 100% {\n transform: scale(1);\n }\n}\n\n@keyframes pk-anim-2 {\n 0% {\n transform: translate(0, 0);\n }\n 100% {\n transform: translate(24px, 0);\n }\n}\n",APP_TARGET="#target",MESSAGE_SELECTOR="#pk-status-message",PAGE_READY_CLASS="pk-page-ready",MESSAGE_TEMPLATE='
',Renderer=function(){function Renderer(e){var t=this;this._domIsReady=!1,this.revealPage=function(){t.domNode&&t.domNode.classList.add(PAGE_READY_CLASS)},this.injectMetaDescription=function(e){if(e&&0!==e.length){window.document.title=e;var t=document.createElement("meta");t.setAttribute("name","description"),t.setAttribute("content","See relevant content for ".concat(e)),document.getElementsByTagName("head")[0].appendChild(t)}},this.domNode=document.querySelector(e)}return Object.defineProperty(Renderer.prototype,"domIsReady",{get:function(){return this._domIsReady},set:function(e){this._domIsReady=e,e&&this.injectStyles(PAGE_STYLES)},enumerable:!1,configurable:!0}),Renderer.prototype.message=function(e,t){if(void 0===t&&(t=""),this.injectHTML(MESSAGE_TEMPLATE),this.domNode){var n=this.domNode.querySelector(MESSAGE_SELECTOR);n&&(n.innerHTML=e)}t&&this.injectMetaDescription(t)},Renderer.prototype.salesBanner=function(e){if(e){var t=e.href,n=e.position,i=e.message,o=e.theme,r=document.createElement("div"),a=n||"",s="HIGHLIGHT"===o?"is-highlighted":"";r.innerHTML=t?'\n \n "):'\n
').concat(i,"
\n "),"BOTTOM"===n?(r.style.marginTop="30px",document.body.appendChild(r)):document.body.prepend(r)}},Renderer.prototype.loading=function(e){var t="a few";e>0&&(t=''.concat(e,"")),this.message('\n
\n
\n
\n
\n
\n
\n \n "))},Renderer.prototype.adBlockMessage=function(){this.message("\n

Ad block detected

\n Please disable your ad blocker and reload the page.\n ")},Renderer.prototype.errorParkingUnavailable=function(){this.message("\n

An Error Occurred

\n

Parking is currently unavailable. We'll be right back.

\n ")},Renderer.prototype.errorParkingServicesDisabled=function(){this.message("\n

An Error Occurred

\n

Services for this domain name have been disabled.

\n ")},Renderer.prototype.errorParkingNoSponsors=function(e){this.message('\n
\n No sponsors\n
\n \n '.concat(window.location.hostname," currently does not have any sponsors for you.\n \n "),e)},Renderer.prototype.imprint=function(e){if(e){var t=document.querySelector("#imprint-text");t&&(t.innerHTML=e.replace(/(?:\r\n|\r|\n)/g,"
"))}},Renderer.prototype.injectStyles=function(e){if(e){var t=document.createElement("style");t.innerHTML=e.toString(),document.head.appendChild(t)}},Renderer.prototype.injectScript=function(e){if(e){var t=document.createElement("script");t.type="text/javascript",t.src=e,document.body.appendChild(t)}},Renderer.prototype.injectJS=function(js){js&&0!==js.length&&eval(js)},Renderer.prototype.injectHTML=function(e){this.domNode?(e&&(this.domNode.innerHTML=e),this.domIsReady=!0):(this.domIsReady=!1,console.error("An error occurred when trying to render this page. DOM node not found."))},Renderer.prototype.prerender=function(e){this.injectMetaDescription(e.domain),this.injectHTML(e.html)},Renderer.prototype.template=function(e){var t,n=this;this.domIsReady||this.prerender(e),this.injectStyles(e.stylesheet),this.imprint(e.imprint),this.salesBanner(e.salesBanner),this.injectJS(e.javascript),null===(t=e.scripts)||void 0===t||t.forEach((function(e){n.injectScript(e)}))},Renderer}(),Render=new Renderer(APP_TARGET),Type;!function(e){e[e.Failed=0]="Failed",e[e.Disabled=1]="Disabled",e[e.Redirect=2]="Redirect",e[e.Parking=3]="Parking",e[e.Sales=4]="Sales"}(Type||(Type={}));var State$2=function(){function e(){}return Object.defineProperty(e.prototype,"trackingType",{get:function(){return this._trackingType},set:function(e){this._trackingType=e},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"track",{get:function(){return!!this.trackingType},enumerable:!1,configurable:!0}),e}(),Disabled=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.type=Type.Disabled,t}return __extends(t,e),t.build=function(e,n){var i;switch(n===Blocking.BLOCKED&&(i="adblocker"),e.cannotPark){case"disabled_mr":case"disabled_rc":i=e.cannotPark}if(i){var o=new t;return o.reason=i,o.domain=e.domainName,o}},Object.defineProperty(t.prototype,"message",{get:function(){switch(this.reason){case"adblocker":return"

Ad block detected

Please disable your ad blocker and reload the page.";case"disabled_mr":return"

Invalid URL

Referral traffic for ".concat(this.domain," does not meet requirements.");default:return"

No sponsors

".concat(this.domain," currently does not have any sponsors for you.")}},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"trackingType",{get:function(){switch(this.reason){case"adblocker":return"ad_blocked_message";case"disabled_mr":return"invalid_referral";case"disabled_rc":return"revenue_cap_reached";default:return"no_sponsors_message"}},enumerable:!1,configurable:!0}),t.prototype.toContext=function(){return{cannotPark:this.reason}},t}(State$2),Failed=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.type=Type.Failed,t}return __extends(t,e),t.cannotPark=function(e){var n=e.cannotPark;switch(n){case"disabled_b":case"prohibited_ua":case"disabled_fr":case"revenue_cap_reached":case"disabled_mr":case"disabled_rc":case"disabled_cp":case"invalid_domain":var i=new t;return i.reason=n,i}},t.noSponsors=function(e){if(e.cannotLoadAds){var n=new t;return n.reason="no_sponsors",n}},t.fromError=function(e){var n=new t;return n.reason="js_error",n.error=e,n},Object.defineProperty(t.prototype,"track",{get:function(){return!!this.trackingType},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"message",{get:function(){switch(this.reason){case"disabled_fr":case"disabled_rc":case"no_sponsors":return"\n

No Sponsors

\n

".concat(this.domain," currently does not have any sponsors for you.

");case"disabled_mr":return"\n

Invalid URL

\n

Referral traffic for ".concat(this.domain," does not meet requirements.

");case"js_error":return"\n

An Error Occurred

\n

Parking is currently unavailable. We'll be right back.

\n ";default:return"\n

An Error Occurred

\n

Services for this domain name have been disabled.

\n "}},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"trackingType",{get:function(){switch(this.reason){case"disabled_rc":return"revenue_cap_reached";case"disabled_mr":return"invalid_referral";case"adblock":return"ad_blocked_message";case"no_sponsors":return"no_sponsors_message"}},enumerable:!1,configurable:!0}),Object.defineProperty(t.prototype,"domain",{get:function(){return window.location.hostname},enumerable:!1,configurable:!0}),t.prototype.toContext=function(){return{cannotPark:this.reason}},t}(State$2);function unpackPHPArrayObject(e,t){var n=e[t];if(n&&!Array.isArray(n))return n}var Parking=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.type=Type.Parking,t}return __extends(t,e),t.build=function(e,n){var i=new t;i.domain=e.domainName,i.html=e.template,i.scripts=e.scripts||[],i.javascript=e.inlineJs,i.stylesheet=e.styles,i.imprint=e.imprintText;var o=unpackPHPArrayObject(e,"salesSettings"),r=(null==o?void 0:o.status)&&"NOT_FOR_SALE"!==(null==o?void 0:o.status);if(r){o.status;var a=o.location,s=o.message,c=o.link,d=o.type;i.salesBanner={message:s,href:c,position:a,theme:d}}return n.wantsToServeAds?i.trackingType="ctr":r&&window.location.pathname.startsWith("/listing")?i.trackingType="sales":i.trackingType="visit",i},t.prototype.toContext=function(){return{}},t}(State$2),Sales=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.type=Type.Sales,t}return __extends(t,e),t.build=function(e){var n=unpackPHPArrayObject(e,"salesSettings");if(n&&"NOT_FOR_SALE"!==n.status)return window.location.pathname.endsWith("/listing")?new t:void 0},t.prototype.toContext=function(){return{}},Object.defineProperty(t.prototype,"trackingType",{get:function(){return"sales"},enumerable:!1,configurable:!0}),t.prototype.init=function(e){window.context=e;var t=document.createElement("script");t.type="text/javascript",t.src=SALES_JS_URL,document.head.append(t)},t}(State$2),Redirect=function(e){function t(){var t=null!==e&&e.apply(this,arguments)||this;return t.type=Type.Redirect,t}return __extends(t,e),t.build=function(e,n,i){var o=unpackPHPArrayObject(e,"salesSettings"),r=e.zeroClickDelay,a=e.skenzoRedirect,s=e.skenzoUrl,c=e.showInquiryForm,d=e.canZeroClick;e.cannotPark;var l="",u=0,p="";if(i.cannotLoadAds?i.wantsToServeAds?(l=window.location.origin,p="no_ads_redirect"):(null==o?void 0:o.status)&&"NOT_FOR_SALE"!==(null==o?void 0:o.status)?l="".concat(window.location.origin,"/listing"):!1!==d&&((null==n?void 0:n.redirect)?(l=n.redirect,u=r||0,p="zc_redirect"):a&&s&&(l=s,p="skenzo_redirect")):!1!==d&&(null==n?void 0:n.reason)?(null==n?void 0:n.redirect)?(l=n.redirect,u=r||0,p="zc_redirect"):a&&s&&(l=s,p="skenzo_redirect"):window.location.pathname.endsWith("/listing")?"EXTERNAL_MARKET"===(null==o?void 0:o.status)&&(null==o?void 0:o.external)?(l=o.external,p="sales"):"URL"===(null==o?void 0:o.status)&&(null==o?void 0:o.link)&&(l=o.link,p="sales"):c&&(l="".concat(window.location.origin,"/listing")),l){var h=new t;return h.url=l,h.delay=u,h.trackingType=p,h}},t.prototype.toContext=function(){return{}},t}(State$2),browserState=function(){var e,t,n,i,o,r,a=window.screen,s=a.width,c=a.height,d=window.self,l=window.top,u=window.matchMedia,p=window.opener,h=document.documentElement,f=h.clientWidth,g=h.clientHeight;try{r=(new Date).getTimezoneOffset()/60*-1}catch(e){r=null}return{popup:!(!p||p===window),timezone_offset:r,user_preference:null===(e=null===Intl||void 0===Intl?void 0:Intl.DateTimeFormat())||void 0===e?void 0:e.resolvedOptions(),user_using_darkmode:Boolean(u&&u("(prefers-color-scheme: dark)").matches),user_supports_darkmode:Boolean(u),window_resolution:{width:null!=f?f:0,height:null!=g?g:0},screen_resolution:{width:null!=s?s:0,height:null!=c?c:0},frame:l===d?null:{innerWidth:null!==(t=null==d?void 0:d.innerWidth)&&void 0!==t?t:0,innerHeight:null!==(n=null==d?void 0:d.innerHeight)&&void 0!==n?n:0,outerWidth:null!==(i=null==d?void 0:d.outerWidth)&&void 0!==i?i:0,outerHeight:null!==(o=null==d?void 0:d.outerHeight)&&void 0!==o?o:0}}},TRACKING_URL="_tr",trackVisit=function(e,t){var n,i=e.callbacks,o=e.context,r=__assign({ad_loaded_callback:null==i?void 0:i.adLoadedCallback,app_version:version,caf_timed_out:null==i?void 0:i.cafTimedOut,channel:null===(n=null==o?void 0:o.pageOptions)||void 0===n?void 0:n.channel,fd_server_datetime:o.fd_server_datetime,fd_server:o.fd_server,flex_rule:o.flex_rule,host:o.host,ip:o.ip,js_error:o.js_error,no_ads_redirect:o.noAdsRedirect,page_headers:o.page_headers,page_loaded_callback:null==i?void 0:i.pageLoadedCallback,page_method:o.page_method,page_request:o.page_request,page_time:o.page_time,page_url:o.page_url,reportable_channel:o.reportableChannel,template_id:o.templateId,type:t,user_has_ad_blocker:o.user_has_ad_blocker,uuid:o.uuid,zeroclick:o.zeroClick},browserState());fetch("/".concat(TRACKING_URL),{method:"POST",headers:{Accept:"application/json","Content-Type":"application/json"},body:JSON.stringify({signature:encode(r)})})},State$1;!function(){if(!window.CustomEvent){function e(e,t){t=t||{bubbles:!1,cancelable:!1,detail:void 0};const n=document.createEvent("CustomEvent");return n.initCustomEvent(e,t.bubbles,t.cancelable,t.detail),n}e.prototype=window.Event.prototype,window.CustomEvent=e}}(),function(e){e[e.Pending=0]="Pending",e[e.Loaded=1]="Loaded",e[e.Failed=2]="Failed"}(State$1||(State$1={}));var Provider=function(){function e(e){var t=this;this.timeoutSeconds=5,this.handlePixelEvent=function(e){switch(t.state){case State$1.Failed:break;case State$1.Pending:setTimeout((function(){return t.handlePixelEvent(e)}),100);break;case State$1.Loaded:t.onPixelEvent(e)}},this.watch=function(){switch(t.state){case State$1.Loaded:case State$1.Failed:break;case State$1.Pending:t.isLoaded()?t.state=State$1.Loaded:t.isTimedOut()?t.state=State$1.Failed:setTimeout(t.watch,50)}},e&&e.length>0?(this.identifier=e,this.state=State$1.Pending,this.timeoutAt=new Date,this.timeoutAt.setSeconds(this.timeoutAt.getSeconds()+this.timeoutAfter()),this.injectPixel()):this.state=State$1.Failed}return e.prototype.injectPixel=function(){this.injectedAt||(this.injectedAt=new Date,this.inject(),this.watch())},e.prototype.inject=function(){var e=document.createElement("script");e.text=this.script,document.head.appendChild(e)},e.prototype.isTimedOut=function(){return+new Date>=+this.timeoutAt},e.prototype.timeoutAfter=function(){return this.timeoutSeconds},e}(),Facebook=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return __extends(t,e),Object.defineProperty(t.prototype,"script",{get:function(){return"!function(f,b,e,v,n,t,s){if(f.fbq)return;n=f.fbq=function(){n.callMethod?n.callMethod.apply(n,arguments):n.queue.push(arguments)};if(!f._fbq)f._fbq=n;n.push=n;n.loaded=!0;n.version='2.0';n.queue=[];t=b.createElement(e);t.async=!0;t.src=v;s=b.getElementsByTagName(e)[0];s.parentNode.insertBefore(t,s)}(window, document,'script','https://connect.facebook.net/en_US/fbevents.js');fbq('init', '".concat(this.identifier,"');")},enumerable:!1,configurable:!0}),t.prototype.onPixelEvent=function(e){window.fbq("trackCustom",e)},t.prototype.isLoaded=function(){return!!window.fbq},t}(Provider),Outbrain=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return __extends(t,e),Object.defineProperty(t.prototype,"script",{get:function(){return"!function(_window, _document) {var OB_ADV_ID = '".concat(this.identifier,"';if (_window.obApi) {var toArray = function(object) {return Object.prototype.toString.call(object) === '[object Array]' ? object : [object];};_window.obApi.marketerId = toArray(_window.obApi.marketerId).concat(toArray(OB_ADV_ID));return;}var api = _window.obApi = function() {api.dispatch ? api.dispatch.apply(api, arguments) : api.queue.push(arguments);};api.version = '1.1';api.loaded = true;api.marketerId = OB_ADV_ID;api.queue = [];var tag = _document.createElement('script');tag.async = true;tag.src = '//amplify.outbrain.com/cp/obtp.js';tag.type = 'text/javascript';var script = _document.getElementsByTagName('script')[0];script.parentNode.insertBefore(tag, script);}(window, document);")},enumerable:!1,configurable:!0}),t.prototype.onPixelEvent=function(e){window.obApi("track",e)},t.prototype.isLoaded=function(){return!!window.obApi},t}(Provider),Revcontent=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return __extends(t,e),Object.defineProperty(t.prototype,"script",{get:function(){return""},enumerable:!1,configurable:!0}),t.prototype.inject=function(){var e=document.createElement("script");e.src="https://assets.revcontent.com/master/rev.js",document.head.appendChild(e)},t.prototype.onPixelEvent=function(e){window.rev("event",e)},t.prototype.isLoaded=function(){return!!window.rev},t}(Provider),Taboola=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return __extends(t,e),Object.defineProperty(t.prototype,"script",{get:function(){return"window._tfa = window._tfa || [];!function (t, f, a, x) {if (!document.getElementById(x)) {t.async = 1;t.src = a;t.id=x;f.parentNode.insertBefore(t, f);}}(document.createElement('script'),document.getElementsByTagName('script')[0],'//cdn.taboola.com/libtrc/unip/1451879/tfa.js','tb_tfa_script');"},enumerable:!1,configurable:!0}),t.prototype.onPixelEvent=function(e){window._tfa.push({notify:"event",name:e,id:this.identifier})},t.prototype.isLoaded=function(){return Array.isArray(window._tfa)},t}(Provider),Tiktok=function(e){function t(){return null!==e&&e.apply(this,arguments)||this}return __extends(t,e),Object.defineProperty(t.prototype,"script",{get:function(){return'!function (w, d, t) {w.TiktokAnalyticsObject=t;var ttq=w[t]=w[t]||[];ttq.methods=["page","track","identify","instances","debug","on","off","once","ready","alias","group","enableCookie","disableCookie"],ttq.setAndDefer=function(t,e){t[e]=function(){t.push([e].concat(Array.prototype.slice.call(arguments,0)))}};for(var i=0;i=n.blocks.length&&(n.state.blocks.transitionTo(State.Failure),n.failureReason="caf_adloadfail_".concat(e)))},this.onTimeout=function(){n.state.script.transitionFromPendingTo(State.TimedOut),n.state.blocks.transitionFromPendingTo(State.TimedOut)},this.blocks=e,this.options=t}return Object.defineProperty(e.prototype,"loaded",{get:function(){return this.state.script.loaded},enumerable:!1,configurable:!0}),e.prototype.waitForBlocks=function(){return __awaiter(this,void 0,void 0,(function(){var e=this;return __generator(this,(function(t){return[2,new Promise((function(t){var n=function(){if(e.state.blocks.done)t();else{var i=e.blocksLoaded.map((function(e){return e.adsLoaded}));i.includes(!1)||i.length>=e.blocks.length?t():setTimeout(n,50)}};n()}))]}))}))},e.prototype.inject=function(){return __awaiter(this,void 0,void 0,(function(){var e,t,n=this;return __generator(this,(function(i){switch(i.label){case 0:return i.trys.push([0,3,,4]),[4,injectScriptTags()];case 1:return i.sent()&&void 0!==window.google?(new((t=window.google.ads.domains.Caf).bind.apply(t,__spreadArray([void 0,__assign(__assign({},this.options),{pageLoadedCallback:this.onPageLoaded,adLoadedCallback:this.onBlockLoaded})],this.blocks,!1))),setTimeout(this.onTimeout,TIMEOUT_CALLBACKS),[4,new Promise((function(e){var t=function(){n.state.script.done?e():setTimeout(t,10)};t()}))]):(this.state.script.transitionTo(State.Failure),[2,void 0]);case 2:return[2,i.sent()];case 3:return e=i.sent(),this.error=e.toString(),[2,void 0];case 4:return[2]}}))}))},e.prototype.toCallbacks=function(){return{adLoadedCallback:this.blocksLoaded.slice(-1)[0],pageLoadedCallback:this.pageLoaded,cafTimedOut:this.state.script.timedOut||this.state.blocks.timedOut,googleAdsFailure:!!this.failureReason}},e.prototype.toContext=function(){var e={cafScriptWasLoaded:this.state.script.loaded,callbacks:this.toCallbacks};return this.error&&(e.js_error={message:this.error}),this.state.script.loaded||(e.zeroClick={reason:"googleAdsFailure"}),e},e.prototype.mockFailedState=function(){this.state.blocks.transitionTo(State.Failure),this.state.script.transitionTo(State.Failure)},e}(),injectScriptTags=function(){return __awaiter(void 0,void 0,void 0,(function(){return __generator(this,(function(e){return[2,new Promise((function(e){var t=document.createElement("script");t.type="text/javascript",t.src=SRC,t.addEventListener("load",(function(){return e(!0)})),t.addEventListener("error",(function(){return e(!1)})),document.body.appendChild(t),setTimeout((function(){return e(!1)}),TIMEOUT_SCRIPTS)}))]}))}))},TagManager=function(){function e(e){this.injected=!1,this.identifier=e}return e.prototype.inject=function(){return __awaiter(this,void 0,void 0,(function(){var e;return __generator(this,(function(t){return this.injected?[2]:this.identifier?("TEST"===this.identifier||((e=document.createElement("script")).setAttribute("src","https://www.googletagmanager.com/gtag/js?id=".concat(this.identifier)),document.head.appendChild(e),this.track(),this.injected=!0),[2]):[2]}))}))},e.prototype.track=function(){this.push("js",new Date),this.push("config",this.identifier)},e.prototype.push=function(e,t){window.dataLayer||(window.dataLayer=[]),window.dataLayer.push([e,t])},e}(),ADS_PARAM="?caf",ADS_TRACKING_URL="_tr",BLOCKS_TYPE="ads",BLOCKS_CONTAINER="rs",Google=function(){function e(e,t,n,i,o){this._blocks=t,this._pageOptions=n,this.uuid=e,this.baseURL=o,this.ads=new Ads(this.blocks,this.pageOptions),this.tagManager=new TagManager(i)}return e.build=function(t,n){var i=t.pageOptions,o=t.preferredLanguage,r=t.blocks,a=t.googleAnalytics,s={};i&&((s=__assign({},i)).hl||(s.hl=o));var c=null==i?void 0:i.resultsPageBaseUrl;return new e(n.uuid,r,s,a,c)},e.prototype.injectTagManager=function(){this.tagManager.inject()},e.prototype.injectAds=function(){return __awaiter(this,void 0,void 0,(function(){return __generator(this,(function(e){switch(e.label){case 0:return[4,this.ads.inject()];case 1:return e.sent(),[2]}}))}))},e.prototype.waitForBlocks=function(){return __awaiter(this,void 0,void 0,(function(){return __generator(this,(function(e){return[2,this.ads.waitForBlocks()]}))}))},Object.defineProperty(e.prototype,"blocks",{get:function(){var e=this;return(this._blocks||[]).filter((function(t){return e.wantsToServeAds?t.type===BLOCKS_TYPE:t.container===BLOCKS_CONTAINER})).map((function(t){var n=parse(),i=__assign({},t);return i.resultsPageBaseUrl="".concat(e.baseURL).concat(ADS_PARAM,"&").concat(n.toString()),e.wantsToServeAds&&(n.append("click","true"),n.append("session",e.uuid),i.clicktrackUrl="".concat(TRACKING_DOMAIN).concat(ADS_TRACKING_URL,"/?").concat(n.toString())),i}))},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"pageOptions",{get:function(){var e=__assign({},this._pageOptions);return Object.keys(this._pageOptions).forEach((function(t){t.startsWith("bodis")&&delete e[t]})),e},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"cannotLoadAds",{get:function(){return!this.ads.loaded},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"wantsToServeAds",{get:function(){return window.location.search.startsWith(ADS_PARAM)},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"adsMode",{get:function(){return this.ads.loaded&&this.wantsToServeAds},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"adsReady",{get:function(){return this.wantsToServeAds&&!this.cannotLoadAds},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"callbacks",{get:function(){return this.ads.toCallbacks()},enumerable:!1,configurable:!0}),e.prototype.toContext=function(){return __assign({blocks:this.blocks,pageOptions:this.pageOptions},this.ads.toContext())},e}(),App=function(){function e(){}return e.prototype.main=function(){var e;return __awaiter(this,void 0,void 0,(function(){var t,n,i,o,r,a,s,c;return __generator(this,(function(d){switch(d.label){case 0:return this.parkResponse=decode(),t=this,[4,getFindDomain()];case 1:if(t.findDomainResponse=d.sent(),!this.findDomainResponse)throw new Error("Domain failed to load.");return this.pixels=Pixels.build(this.findDomainResponse),null===(e=this.pixels)||void 0===e||e.listenForEvents(),this.adblock=new Adblock,this.google=Google.build(this.findDomainResponse,this.parkResponse),this.google.injectTagManager(),n=Parking.build(this.findDomainResponse,this.google),Render.prerender(n),i=Promise.all([this.adblock.inject(),this.google.injectAds()]),(o=Failed.cannotPark(this.findDomainResponse))?[4,this.transitionToFailed(o)]:[3,3];case 2:return d.sent(),[2];case 3:return[4,i];case 4:return d.sent(),(r=Disabled.build(this.findDomainResponse,this.adblock.state))?[4,this.transitionToDisabled(r)]:[3,6];case 5:return d.sent(),[2];case 6:return this.eligibleForZeroClick?(a=this,[4,getZeroClick(this.context)]):[3,8];case 7:a.zeroClickResponse=d.sent(),d.label=8;case 8:return(s=Redirect.build(this.findDomainResponse,this.zeroClickResponse,this.google))?[4,this.transitionToRedirect(s)]:[3,10];case 9:return d.sent(),[2];case 10:return(c=Sales.build(this.findDomainResponse))?[4,this.transitionToSales(c)]:[3,12];case 11:return d.sent(),[2];case 12:return(o=Failed.noSponsors(this.google))?[4,this.transitionToFailed(o)]:[3,14];case 13:return d.sent(),[2];case 14:return[4,this.transitionToParking(n)];case 15:return d.sent(),[2]}}))}))},e.prototype.transitionToParking=function(e){return __awaiter(this,void 0,void 0,(function(){return __generator(this,(function(t){switch(t.label){case 0:return this.state=e,Render.template(e),Render.revealPage(),[4,this.google.waitForBlocks()];case 1:return t.sent(),[4,this.track()];case 2:return t.sent(),[2]}}))}))},e.prototype.transitionToRedirect=function(e){return __awaiter(this,void 0,void 0,(function(){var t;return __generator(this,(function(n){switch(n.label){case 0:return this.state=e,t=this.track(),Render.revealPage(),[4,waiter(e.delay,(function(e){return Render.loading(e)}))];case 1:return n.sent(),[4,t];case 2:return n.sent(),window.location.href=e.url,log("➡ Redirecting [".concat(e.url,"]")),[2]}}))}))},e.prototype.transitionToFailed=function(e){return __awaiter(this,void 0,void 0,(function(){return __generator(this,(function(t){switch(t.label){case 0:return this.state=e,Render.message(e.message),Render.revealPage(),[4,this.track()];case 1:return t.sent(),[2]}}))}))},e.prototype.transitionToSales=function(e){return __awaiter(this,void 0,void 0,(function(){return __generator(this,(function(t){switch(t.label){case 0:return this.state=e,e.init(this.context),[4,this.track()];case 1:return t.sent(),[2]}}))}))},e.prototype.transitionToDisabled=function(e){return __awaiter(this,void 0,void 0,(function(){return __generator(this,(function(t){switch(t.label){case 0:return this.state=e,Render.message(e.message),Render.revealPage(),[4,this.track()];case 1:return t.sent(),[2]}}))}))},e.prototype.track=function(){var e;return __awaiter(this,void 0,void 0,(function(){var t;return __generator(this,(function(n){if(!this.state.track)return[2,Promise.resolve()];try{return t=this.state.trackingType,null===(e=this.pixels)||void 0===e||e.dispatchEvent({type:t}),[2,trackVisit({context:this.context,callbacks:this.google.callbacks},t)]}catch(e){return[2,void 0]}return[2]}))}))},Object.defineProperty(e.prototype,"eligibleForZeroClick",{get:function(){var e=this.findDomainResponse,t=e.cannotPark,n=e.canZeroClick,i=e.zeroClick,o=this.google.cannotLoadAds;return!!t||(!(!n||!o)||!!(null==i?void 0:i.reason))},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"channel",{get:function(){var e,t,n=this,i=n.adblock,o=n.google.adsMode,r=n.findDomainResponse.reportableChannel,a=(null===(t=null===(e=this.findDomainResponse)||void 0===e?void 0:e.pageOptions)||void 0===t?void 0:t.channel)||"";return i.state===Blocking.ALLOWED&&(a=a.concat(",pid-bodis-gcontrol98")),o&&r&&(a=a.concat(",pid-bodis-gcontrol".concat(r))),a},enumerable:!1,configurable:!0}),Object.defineProperty(e.prototype,"context",{get:function(){var e,t,n,i,o,r=__assign(__assign(__assign(__assign(__assign(__assign(__assign({app_version:APP_VERSION},this.parkResponse),this.findDomainResponse),{pageOptions:null===(e=this.findDomainResponse)||void 0===e?void 0:e.pageOptions,zeroClick:__assign(__assign({},null===(t=this.findDomainResponse)||void 0===t?void 0:t.zeroClick),this.zeroClickResponse)}),null===(n=this.adblock)||void 0===n?void 0:n.toContext()),null===(i=this.google)||void 0===i?void 0:i.toContext()),null===(o=this.state)||void 0===o?void 0:o.toContext()),browserState());return r.pageOptions.channel=this.channel,r},enumerable:!1,configurable:!0}),e.prototype.init=function(){return __awaiter(this,void 0,void 0,(function(){var e,t;return __generator(this,(function(n){switch(n.label){case 0:n.label=1;case 1:return n.trys.push([1,3,,4]),window.__parkour=this,[4,this.main()];case 2:return n.sent(),[3,4];case 3:return e=n.sent(),console.error("app",e),t=Failed.fromError(e),this.state=t,Render.message(t.message),Render.revealPage(),[3,4];case 4:return[2]}}))}))},e}();(new App).init(),exports.App=App}));